For the Acquisition of Quantitative Imaging Biomarkers (QIBs)
What are QIBs?
Quantitative imaging biomarkers (QIBs) are physical measurands extracted from clinical imaging techniques. They allow for robust longitudinal assessments due to high confidence in bias and precision, increased reproducibility of image acquisition, and clinical trial endpoints that lower the sample size required for adequate power. Validated QIBs should be acquired using standardized technical specifications, such as found in QMIC Technical Guidelines.
How can I use QMIC Technical Guidelines?
The guidelines below are digitally published and clinically feasible step-by-step guides to help your team implement quantitative imaging in clinical practice and clinical trials.
Who created QMIC Technical Guidelines?
Many of the QMIC Technical Guidelines originated from committees formed within the Radiological Society of North America (RSNA) Quantitative Imaging Biomarker Alliance (QIBA). QMIC is grateful for the longstanding support of RSNA QIBA, which brought together experts in these fields and enabled original guideline publications to reach clinical feasibility.
MRI Guidelines
Magnetic Resonance Elastography of the Liver
November 7, 2023
published by the MRE Biomarker Committee
When referencing this document, please use the following format:
QIBA MR Elastography Biomarker Committee. MR Elastography of the Liver, Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible. Maintenance version. November 7, 2023. DOI:10.1148/QIBA/20231107
Magnetic Resonance Diffusion-Weighted Imaging (DWI) of the Apparent Diffusion Coefficient (ADC)
December 2022
published by the DWI Biomarker Committee
When referencing this document, please use the following format:
QIBA MR Diffusion-Weighted Imaging Biomarker Committee. MR Diffusion-Weighted Imaging (DWI) of the Apparent Diffusion Coefficient (ADC), Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible. December 15, 2022. DOI:10.1148/QIBA/20221215
CT Guidelines
Atherosclerosis Biomarkers by Computed Tomography Angiography (CTA)
June 2024
published by the CTA Biomarker Committee
When referencing this document, please use the following format:
QIBA CT Atherosclerosis Biomarker Committee. CT Atherosclerosis Biomarkers, Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible: Maintenance draft. June, 2024. DOI:10.1148/QIBA/202406
Small Lung Nodule Volume Assessment and Monitoring in Low Dose CT Screening
June 2024
published by the SLN Biomarker Committee
When referencing this document, please use the following format:
QIBA CT Small Lung Nodule Biomarker Committee. CT Small Lung Nodule Volume Assessment and Monitoring in Low Dose Screening, Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible. December 19, 2023. DOI:10.1148/QIBA/20231219
CT Tumor Volume Change for Advanced Disease (CTV-AD)
July 2022
published by the VolCT Biomarker Committee
When referencing this document, please use the following format:
QIBA CT Volumetry Biomarker Committee. CT Tumor Volume Change for Advanced Disease (CTV-AD) Profile, Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible. July 21, 2022. DOI:10.1148/QIBA/20220721
Nuclear/Molecular/PET Guidelines
QIBA Profile. FDG-PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy
June 2023
published by the FDG-PET Biomarker Committee
When referencing this document, please use the following format:
QIBA FDG-PET/CT Biomarker Committee. FDG-PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy, Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible, Version 1.14. November 18, 2016, updated June 15, 2023. DOI:10.1148/QIBA/20230615
18F-labeled PET tracers targeting Amyloid as an Imaging Biomarker
June 2022
published by the PET Amyloid Biomarker Committee
When referencing this document, please use the following format:
QIBA PET Amyloid Biomarker Committee. 18F-labeled PET tracers targeting 4 Amyloid as an Imaging Biomarker, Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible. June 1, 2022.
Ultrasound Guidelines
Ultrasound Measurement of Shear Wave Speed for Estimation of Liver Fibrosis
January 2024
published by the Ultrasound SWS Biomarker Committee
When referencing this document, please use the following format:
QIBA US Shear Wave Speed Biomarker Committee. US Shear Wave Speed for Liver Fibrosis, Quantitative Imaging Biomarkers Alliance. Profile Stage: Clinically Feasible. January 15, 2024. DOI:10.1148/QIBA/20240115
SWS Checklists Appendix E
December 2023
published by the Ultrasound SWS Biomarker Committee
